Which medication is known to affect successful contact lens wear?

Antihistamines are known to affect successful contact lens wear primarily due to their side effects, particularly their impact on tear production and ocular moisture. These medications are commonly used to treat allergies, colds, or other conditions that lead to histamine release. A significant side effect of antihistamines is dryness, which can lead to discomfort when wearing contact lenses. When tear production decreases, it can result in insufficient lubrication for the lenses, leading to irritation, potential blinking issues, or lens intolerance.

In contrast, while antacids, aspirin, and laxatives serve important roles in treating digestive or pain-related issues, their primary effects do not typically interfere with ocular health or comfort in relation to contact lens wear. They are less likely to cause dryness or impact tear film stability in a way that directly affects how well a person can wear contact lenses. Therefore, the role of antihistamines in reducing moisture and comfort makes them the most relevant choice in this context.